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It is critical that there is a reliable supply of Avastin for intravitreal injection, which is a highly cost effective, sight-saving drug for a variety of retinal diseases. The FDA and state pharmacy boards have developed Federal and State legislation to address some of these concerns. Ultimately, it is imperative that physicians have oversight and input regarding the quality and safety of their Avastin supply and work directly with their compounding pharmacy to ensure the highest possible standards.